Shedding Light on IDH1 Mutation in Gliomas

IDH1 Mutation in Gliomas in Mosul City - Iraq

BACKGROUND IDH1 (isocitrate dehydrogenase 1) mutation might be encounter in the low grade glioma and directs the progression of the tumor to a higher grade. OBJECTIVE To assess the frequency of IDH1 mutations in gliomas and to correlate the IDH1 positivity with the type and grade of tumors, the age and sex of the patients. MATERIAL AND METHODS A retro- and prospective case series study. One...

Mutation Analysis of IDH1 in Paired Gliomas Revealed IDH1 Mutation Was Not Associated with Malignant Progression but Predicted Longer Survival

Recurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 status at codon 132 of IDH1 and codon 172 of IDH2 by direct sequencing and anti-IDH1-R132H immunohi...

Metabolism, gliomas, and IDH1.

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation.

OBJECTIVE To explore whether the isocitrate dehydrogenase 1 (IDH1) or 1p/19q status determines the prognostic vs predictive role of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in the Neuro-Oncology Working Group of the German Cancer Society (NOA)-04 trial anaplastic glioma biomarker cohort. METHODS Patients (n = 183) of the NOA-04 trial with known MGMT and IDH1 status...

Shedding Light on Light*

There are four books describing early studies and views on light, optics and vision that are considered to be landmarks in this branch of science. The first of these is Euclid’s Optica, published about 300BC, in which he postulated that light travelled in straight lines; he described the laws of reflection and described them mathematically. The second is by Ptolemy. He is best known for his 15 ...